Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atox1Gt(IRESBetageo)3Pgr
Name:	antioxidant 1 copper chaperone; gene trap 3, Peter Gruss
MGI ID:	MGI:2158341
Synonyms:	Atox1-
Gene:	Atox1  Location: Chr11:55337463-55352034 bp, - strand  Genetic Position: Chr11, 33.07 cM
Alliance:	Atox1Gt(IRESBetageo)3Pgr page

Germline Transmission:	Earliest citation of germline transmission: J:74249
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The gene was disrupted by the insertion of the gene trap vector IRES Beta-geo into intron 1. Northern blot analysis on RNA derived from E12.5 embryonic fibroblasts from homozygous mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on protein derived from E12.5 embryonic fibroblasts revealed that no detectable wild-type protein was made. (J:74249)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atox1 Mutation:	13 strains or lines available

Original:	J:74249 Hamza I, et al., The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6848-52
All:	6 reference(s)