Derm1<NC/Nga> QTL Variant Detail MGI Mouse (MGI:2157106)

Derm1^NC/Nga
QTL Variant Detail

Summary

QTL variant:	Derm1^NC/Nga
Name:	dermatitis 1; NC/Nga
MGI ID:	MGI:2157106
QTL:	Derm1 Location: unknown Genetic Position: Chr9, cM position of peak correlated region/allele: 33.34 cM
QTL Note:	genome coordinates based on the marker associated with the peak LOD score

Variant
origin

Strain of Specimen:

NC/Nga

Variant
description

Allele Type:		QTL
Mutation:		Undefined
		This allele confers susceptibility to atopic dermatitis (AD) compared to MSM/Ms. (J:68698)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68698

Mouse strain NC/Nga is a model for human dermatitis. In an effort to map the gene or genes responsible for dermatitis in mice a genome wide scan was employed using 93 segregrants from a (NC/Nga x MSM/MS)F1 x NC backcross. Only backcross mice which exhibited severe dermatitis, were informative. A dermatitis locus (derm) significantly (chi square 16.4) segregated with markers D9Mit163, D9Mit72, D9Mit143, D9Mit103, D9Mit207 and D9Mit209 on mouse Chromosome 9. The authors suggest that Csk could be a candidate for the dermatitis phenotype in the NC/Nga strain. Authors used Derm1 for Derm.

References

Original:	J:68698 Kohara Y, et al., A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics. 2001 Feb;53(1):15-21
All:	5 reference(s)

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