Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Itgb1tm1Mll
Name:	integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Ulrich Muller
MGI ID:	MGI:2156945
Synonyms:	B1-loxP1, beta1-flox, Itb1fl, Itgbeta1flox, Itgbeta1fx
Gene:	Itgb1  Location: Chr8:129412135-129459681 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Alliance:	Itgb1tm1Mll page

Germline Transmission:	Earliest citation of germline transmission: J:71122
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted flanking the first coding exon as follows: One loxP site was inserted 5' to the exon and a loxP-flanked neomycin and thymidine kinase selection cassette was inserted 3' to the exon. The neomycin and thymidine kinase selection cassette was removed via Cre-mediated recombination in ES cells prior to creation of chimeric mice, leaving one loxP site in place of the cassette. (J:71122)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	48 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Itgb1tm1Mll

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:	59 strains or lines available

Original:	J:71122 Graus-Porta D, et al., Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001 Aug 16;31(3):367-79
All:	34 reference(s)