Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Myo7a4494SB
Name:	myosin VIIA; shaker 4494SB
MGI ID:	MGI:2155421
Synonyms:	Myo7ash1-4R, sh14494SB, sh1OR-4494SB
Gene:	Myo7a  Location: Chr7:97700267-97768731 bp, - strand  Genetic Position: Chr7, 53.57 cM
Alliance:	Myo7a4494SB page

Strain of Origin:

BALB/cRl

Allele Type:    Chemically induced (ENU) Mutation:    Inversion   Mutation details: A small 6 nt inversion and substitution of two T nucleotides with a single A resulted in a frameshift and introduction of a stop codon 5 amino acids downstream in the encoded protein. This mutation is predicted to lie in the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that less than 1% of the normal level of the protein was expressed. (J:49926) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:	118 strains or lines available

Original:	J:73419 Rinchik EM, et al., Reverse genetics in the mouse and its application to the study of deafness. Ann N Y Acad Sci. 1991;630:80-92
All:	6 reference(s)