Col11a2tm1Mne
Targeted Allele Detail
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Symbol: |
Col11a2tm1Mne |
Name: |
collagen, type XI, alpha 2; targeted mutation 1, Richard Mayne |
MGI ID: |
MGI:2154689 |
Gene: |
Col11a2 Location: Chr17:34258411-34285659 bp, + strand Genetic Position: Chr17, 17.98 cM
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Alliance: |
Col11a2tm1Mne page
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Germline Transmission: |
Earliest citation of germline transmission:
J:71948
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin-resistance cassette was inserted between restriction sites in exons 27 and 28. A short, aberrant trancript was produced from the targeted allele, which could be detected by Northern blotting. However, translation of the full-length protein is predicted to result in a truncated protein, due to the presence of termination codons.
(J:71948)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Col11a2 Mutation: |
63 strains or lines available
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Original: |
J:71948 Li SW, et al., Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Dev Dyn. 2001 Oct;222(2):141-52 |
All: |
4 reference(s) |
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