Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Pthlhtm1Hmk Name: parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg MGI ID: MGI:2154515 Synonyms: PTHrP- Gene: Pthlh  Location: Chr6:147153607-147165511 bp, - strand  Genetic Position: Chr6, 78.19 cM, cytoband F-G Alliance: Pthlhtm1Hmk page

Alizarin red S stained skeletal images of hemizygous and homozygous Tg(Col2a1-PTHR1*H223R)AHju and Pthlhtm1Hmk/Pthlhtm1Hmk mice Show the 10 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:16911
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 1.2 kb of sequence including exon IV, which contains most of the coding region. (J:16911)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	25 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pthlh Mutation:	19 strains or lines available

Original:	J:16911 Karaplis AC, et al., Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994 Feb 1;8(3):277-89
All:	47 reference(s)