Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pdx1tm1Ted
Name:	pancreatic and duodenal homeobox 1; targeted mutation 1, Thomas Edlund
MGI ID:	MGI:2152755
Synonyms:	Ipf1-, pdx1-
Gene:	Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Alliance:	Pdx1tm1Ted page

Germline Transmission:	Earliest citation of germline transmission: J:20779
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 2, deleting sequences that encode the homeodomain, the splice acceptor site, and flanking intron sequences. Whole-mount immunohistochemical studies did not detect protein in homozygous mutant embryos. (J:20779)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	14 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:	35 strains or lines available

Original:	J:20779 Jonsson J, et al., Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994 Oct 13;371(6498):606-9
All:	19 reference(s)