Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adora2atm1Map
Name:	adenosine A2a receptor; targeted mutation 1, Marc Parmentier
MGI ID:	MGI:2152583
Synonyms:	A2AAR-, A2AKO, A2aR-
Gene:	Adora2a  Location: Chr10:75152711-75170618 bp, + strand  Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Alliance:	Adora2atm1Map page

Germline Transmission:	Earliest citation of germline transmission: J:42276
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 was replaced with a neomycin selection cassette. Northern blotting and in situ hybridization experiments confirmed that no detectable transcript is produced from this allele. (J:42276)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora2a Mutation:	36 strains or lines available

Original:	J:42276 Ledent C, et al., Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor [see comments]. Nature. 1997 Aug 14;388(6643):674-8
All:	73 reference(s)