Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gnaltm1Rax
Name:	guanine nucleotide binding protein, alpha stimulating, olfactory type; targeted mutation 1, Richard Axel
MGI ID:	MGI:2151207
Synonyms:	Galphaolf, G-olf-
Gene:	Gnal  Location: Chr18:67221369-67359863 bp, + strand  Genetic Position: Chr18, 39.85 cM
Alliance:	Gnaltm1Rax page

Germline Transmission:	Earliest citation of germline transmission: J:45534
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A Pgk-neomycin resistance cassette replaced 1.65kb of sequence that includes the first four exons of the gene. RNA in situ hybridization analysis did not detect transcripts in olfactory sensory neurons of 5-day old homozygous mutant mice. Immunohistochemistry analysis showed reduced staining on olfactory bulb sections derived from 5-day old homozygous mutant mice. (J:45534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnal Mutation:	27 strains or lines available

Original:	J:45534 Belluscio L, et al., Mice deficient in G(olf) are anosmic. Neuron. 1998 Jan;20(1):69-81
All:	20 reference(s)