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Hcrttm1Ywa
Targeted Allele Detail
Summary
Symbol: Hcrttm1Ywa
Name: hypocretin; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:2151182
Synonyms: OKO, orexin knockout, orexin KO, orexin-tau-LacZ, ORX-KO, Ox-
Gene: Hcrt  Location: Chr11:100652519-100653757 bp, - strand  Genetic Position: Chr11, 63.6 cM
Alliance: Hcrttm1Ywa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57124
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin-lacZ cassette replaced exon 1 of the gene. In situ hybridization, immunohistochemistry, and radioimmunoassay of homozygous mutant mice brain failed to detect either orexin-A or orexin-B peptides. (J:57124, J:136109)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hcrt Mutation:  19 strains or lines available
References
Original:  J:57124 Chemelli RM, et al., Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999 Aug 20;98(4):437-51
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory