Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sema3ctm1.1Jra
Name:	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; targeted mutation 1.1, Jonathan A Raper
MGI ID:	MGI:2150759
Synonyms:	Sema3C-, Sema3C(neoout)
Gene:	Sema3c  Location: Chr5:17779814-17935266 bp, + strand  Genetic Position: Chr5, 7.99 cM
Alliance:	Sema3ctm1.1Jra page

Germline Transmission:	Earliest citation of germline transmission: J:71240
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: This allele is a derivative of Sema3ctm1Jra in which the neomycin resistance gene was removed by Cre mediated recombination by crossing mice that carry the Sema3c allele to mice that express Cre recombinase in the germ cell. mRNA in homozygous mutant E12.5 embryos was barely detectable by in situ hybridization. RT-PCR analysis of these embryos detected transcript from regions 5' and 3' of the targeted sequences, but did not detect transcript from a region internal to the targeted sequences. (J:71240)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema3c Mutation:	45 strains or lines available

Original:	J:71240 Feiner L, et al., Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development. 2001 Aug;128(16):3061-70
All:	8 reference(s)