Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Eya1tm1Rilm Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas MGI ID: MGI:2150426 Synonyms: Eya1- Gene: Eya1  Location: Chr1:14239178-14380459 bp, - strand  Genetic Position: Chr1, 4.31 cM Alliance: Eya1tm1Rilm page

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1tm1Mair and Eya1tm1Rilm Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:57313
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin cassette replaced exons 10-13, encoding 153 residues of the Eya domain. (J:57313)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	195 assay results
In Structures Affected by this Mutation:	57 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eya1 Mutation:	54 strains or lines available

Original:	J:57313 Xu PX, et al., Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
All:	29 reference(s)