Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dpp4tm1Nwa
Name:	dipeptidylpeptidase 4; targeted mutation 1, Nicolai Wagtmann
MGI ID:	MGI:2150161
Synonyms:	CD26-, DP-IV-
Gene:	Dpp4  Location: Chr2:62160417-62242575 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Alliance:	Dpp4tm1Nwa page

Germline Transmission:	Earliest citation of germline transmission: J:62709
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 2.3kb segment of the gene, including part of the promoter and all of exons 1 and 2, which encode the cytoplasmic and transmembrane domains of the protein. Flow cytometric analysis of thymocytes from homozygous mutantt mice stained with anti-Dpp4 mAb showed no protein expression. ELISA measurements showed undetectable protein concentrations in the plasma of homozygous mutant mice. (J:62709)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:	73 strains or lines available

Original:	J:62709 Marguet D, et al., Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9
All:	38 reference(s)