Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irs4tm1Lhd
Name:	insulin receptor substrate 4; targeted mutation 1, Gustav E Lienhard
MGI ID:	MGI:2149726
Synonyms:	Irs4-, IRS-4 null
Gene:	Irs4  Location: ChrX:140493994-140508213 bp, - strand  Genetic Position: ChrX, 62.43 cM
Alliance:	Irs4tm1Lhd page

Germline Transmission:	Earliest citation of germline transmission: J:59964
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced the entire coding sequence of the gene except for 457 bp at the 3' end. Reverse transcription-PCR detected no mRNA expression in brain, skeletal muscle, kidney, or liver of homozygous mutant mice. (J:59964)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irs4 Mutation:	5 strains or lines available

Original:	J:59964 Fantin VR, et al., Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E127-33
All:	4 reference(s)