About   Help   FAQ
Fabp4tm1Brsp
Targeted Allele Detail
Summary
Symbol: Fabp4tm1Brsp
Name: fatty acid binding protein 4, adipocyte; targeted mutation 1, Bruce M Spiegelman
MGI ID: MGI:2148887
Synonyms: A-FABP/aP2, aP2-
Gene: Fabp4  Location: Chr3:10269406-10273653 bp, - strand  Genetic Position: Chr3, 2.56 cM
Alliance: Fabp4tm1Brsp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70953
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette disrupted the gene after the transcription start site and before a translation start site at a Pst I site. Absence of mRNA expression in adipose tissue was shown by Northern blot and RT-PCR in homozygous mice. Immunoblot analysis of adipose tissue showed no detectable protein. (J:70953)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fabp4 Mutation:  42 strains or lines available
References
Original:  J:70953 Johnson RS, et al., Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science. 1989 Sep 15;245(4923):1234-6
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory