Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Mstntm1Sjl Name: myostatin; targeted mutation 1, Se-Jin Lee MGI ID: MGI:2148177 Synonyms: mstn-, MSTN-KO Gene: Mstn  Location: Chr1:53100799-53107238 bp, + strand  Genetic Position: Chr1, 26.99 cM Alliance: Mstntm1Sjl page

Skeletal defects in Gdf11tm1Sjl/Gdf11tm1Sjl and Mstntm1Sjl/Mstntm1Sjl Gdf11tm1Sjl/Gdf11tm1Sjl newborn mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:40054
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the sequences encoding the entire C-terminal region of the protein with a neomycin cassette. (J:40054)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mstn Mutation:	33 strains or lines available

Original:	J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
All:	89 reference(s)