Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sparctm1Cam
Name:	secreted acidic cysteine rich glycoprotein; targeted mutation 1, University of Cambridge
MGI ID:	MGI:2137432
Gene:	Sparc  Location: Chr11:55284985-55310906 bp, - strand  Genetic Position: Chr11, 33.04 cM, cytoband B1
Alliance:	Sparctm1Cam page

Germline Transmission:	Earliest citation of germline transmission: J:47014
Parent Cell Line:	CCB (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of exon 6 with a splice acceptor-lacZ gene followed by a neomycin resistance cassette. Northern analysis did not detect transcript in E15.5 homozygous embryos. (J:47014)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sparc Mutation:	75 strains or lines available

Original:	J:47014 Gilmour DT, et al., Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998 Apr 1;17(7):1860-70
All:	9 reference(s)