Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ntn1Gt(IRESBetageo)1Pgr
Name:	netrin 1; gene trap 1, Peter Gruss
MGI ID:	MGI:2137018
Gene:	Ntn1  Location: Chr11:68100190-68277652 bp, - strand  Genetic Position: Chr11, 41.45 cM, cytoband B3
Alliance:	Ntn1Gt(IRESBetageo)1Pgr page

Germline Transmission:	Earliest citation of germline transmission: J:57002
Parent Cell Line:	MPI-II (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The gene trap integration event occurred in an intron of the netrin 1 gene. Integration of the vector resulted in the production of a transcript that included sequences from the 5' end of the gene fused to the vector sequences. Two translation products were produced from this allele: an N-terminal truncated form of the protein including the signal peptide and domains V1 and an IRES driving expression of beta-geo. (J:57002)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	79 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntn1 Mutation:	106 strains or lines available

Original:	J:40076 Chowdhury K, et al., Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 1997 Apr 15;25(8):1531-6
All:	7 reference(s)