Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tp(Y)1CtSxr-b
Name:	transposition, Chr Y, Cattanach 1; Sex reversed, b variant
MGI ID:	MGI:2136318
Synonyms:	HY-, Sxr'
Gene:	Tp(Y)1Ct  Location: unknown  Genetic Position: ChrY, Syntenic

Strain of Origin:

T16H stock

Allele Type:    Spontaneous Mutations:    Deletion, Translocation   Tp(Y)1CtSxr-b involves 3 genes/genome features (Hya, Zfy1, Zfy2) View all   Mutation details: At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1CtSxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lack one of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1CtSxr-b from Tp(Y)1CtSxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya. (J:9332) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	25 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tp(Y)1Ct Mutation:	4 strains or lines available

Original:	J:7662 McLaren A, et al., Male sexual differentiation in mice lacking H-Y antigen. Nature. 1984 Dec 6-12;312(5994):552-5
All:	27 reference(s)