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Gene Expression Data
Assay Details
Assay
Reference: J:32953 Fitzpatrick DR, et al., Differential expression of TGF beta isoforms in murine palatogenesis. Development. 1990 Jul;109(3):585-95
Assay type: RNA in situ
MGI Accession ID: MGI:2136298
Gene symbol: Tgfb2
Gene name: transforming growth factor, beta 2
Probe: Tgfb2 probe2
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen not shown: embryonic day 11.5 (more )
Note: very early palatal shelves
Structure Level Pattern Image Note
TS19: palatal shelf Absent

Specimen not shown: embryonic day 12.5 (more )
Note: early palatal shelves
Structure Level Pattern Image Note
TS20: palatal shelf Absent

Specimen 1D: embryonic day 13.5 (more )
Note: late vertical palatal shelves
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Strong Regionally restricted 1D In some sections, high levels of expression in epithelial cells within hyperplastic nodules in medial edge epithelium.

Specimen 1F: embryonic day 13.5 (more )
Note: late vertical palatal shelves
Structure Level Pattern Image Note
TS21: palatal shelf epithelium Strong Regionally restricted 1F In some sections, high levels of expression in epithelial cells within hyperplastic nodules in medial edge epithelium.

Specimen not shown: embryonic day 13.5 (more )
Note: late vertical palatal shelves
Structure Level Pattern Image Note
TS21: olfactory epithelium Present Regionally restricted Expression in olfactory epithelium of the nasal process

Specimen 2E: embryonic day 14.0 (more )
Note: horizontal palatal shelves
Structure Level Pattern Image Note
TS22: palatal shelf epithelium Absent 2E
TS22: palatal shelf mesenchyme Present Graded 2E Gradient of expression within the mesenchyme beneath the medial epithelium; highest expression levels immediately adjacent to the epithelium.

Specimen 3C: embryonic day 14.5 (more )
Note: fusing palate
Structure Level Pattern Image Note
TS22: palatal shelf mesenchyme Present Regionally restricted 3C Transcript levels increase; easily seen in mesenchyme on either side of the epithelial seam; asymmetric distribution with higher concentration toward nasal side of palate.

Specimen 3E,F: embryonic day 14.5 (more )
Note: fusing palate
Structure Level Pattern Image Note
TS22: palatal shelf mesenchyme Present Regionally restricted 3E , 3F Transcript levels increase; easily seen in mesenchyme on either side of the epithelial seam; asymmetric distribution with higher concentration toward nasal side of palate.
TS22: palatal shelf epithelium Absent 3F , 3E No expression in the epithelial seam itself.

Specimen 4C: embryonic day 15.5 (more )
Note: maturing palate
Structure Level Pattern Image Note
TS23: palatal shelf mesenchyme Present Regionally restricted 4C Diffuse expression in mesenchyme around the midline of the palate.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory