Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cxcr4tm1Tng
Name:	C-X-C motif chemokine receptor 4; targeted mutation 1, Takashi Nagasawa
MGI ID:	MGI:1934442
Synonyms:	CXCR4-
Gene:	Cxcr4  Location: Chr1:128515936-128520030 bp, - strand  Genetic Position: Chr1, 56.43 cM
Alliance:	Cxcr4tm1Tng page

Germline Transmission:	Earliest citation of germline transmission: J:69256
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced most of exon 2 including all of the sequences encoding the transmembrane regions. RT-PCR of E18.5 embryos did not detect transcript in liver tissue from homozygous animals. (J:69256)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:	40 strains or lines available

Original:	J:69256 Tachibana K, et al., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4
All:	29 reference(s)