Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Criptotm1Mms
Name:	cripto, EGF-CFC family member; targeted mutation 1, Michael M Shen
MGI ID:	MGI:1934206
Synonyms:	Cripto-, CriptolacZ
Gene:	Cripto  Location: Chr9:110768676-110775226 bp, - strand  Genetic Position: Chr9, 60.79 cM
Alliance:	Criptotm1Mms page

Germline Transmission:	Earliest citation of germline transmission: J:50343
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region was replaced by a contstruct containing a promoterless lacZ and PGK-neo. Beta-galactosidase staining of heterozygous embryos showed the expression pattern of the lacZ gene to lag that of the endogenous gene. (J:50343)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	123 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cripto Mutation:	56 strains or lines available

Original:	J:50343 Ding J, et al., Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
All:	10 reference(s)