Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Dgat1tm1Far Name: diacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese MGI ID: MGI:1934012 Gene: Dgat1  Location: Chr15:76386215-76396153 bp, - strand  Genetic Position: Chr15, 35.99 cM Alliance: Dgat1tm1Far page

Enhanced epidermal response to topical retinol treatment in Dgat1tm1Far/Dgat1tm1Far mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:61885
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing sequences encoding the carboxy-terminus of the protein was replaced by a neomycin cassette. Northern blot analysis did not detect a full length transcript produced from this allele in homozygous mice. Tissue DGAT activity was absent ot severely reduced in homozygous mice. (J:61885)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dgat1 Mutation:	32 strains or lines available

Original:	J:61885 Smith SJ, et al., Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat [see comments]. Nat Genet. 2000 May;25(1):87-90
All:	33 reference(s)