Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd14tm1Frm
Name:	CD14 antigen; targeted mutation 1, Mason W Freeman
MGI ID:	MGI:1934009
Synonyms:	CD14-
Gene:	Cd14  Location: Chr18:36858120-36859851 bp, - strand  Genetic Position: Chr18, 19.46 cM
Alliance:	Cd14tm1Frm page

Germline Transmission:	Earliest citation of germline transmission: J:65107
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the entire coding sequences of the gene. Western blot analysis confirmed an absence of CD14 protein in macrophage lysates derived from homozygous mice. (J:65107)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd14 Mutation:	23 strains or lines available

Original:	J:65107 Moore KJ, et al., Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15;165(8):4272-80
All:	104 reference(s)