Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdkn1atm1Tyj
Name:	cyclin dependent kinase inhibitor 1A; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:1933751
Synonyms:	Cdkn1a-, p21-, p21cip-
Gene:	Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Alliance:	Cdkn1atm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:68068
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding sequences were replaced by a neomycin cassette. No protein was detected by immunoprecipitation of ES cell lysates in which both alleles were disrupted. (J:68068) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdkn1atm1Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:	60 strains or lines available

Original:	J:68068 Brugarolas J, et al., Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 1995 Oct 12;377(6549):552-7
All:	192 reference(s)