Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ttpatm1Far Name: tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese MGI ID: MGI:1932559 Synonyms: alpha-TTP-KO, Ttpa- Gene: Ttpa  Location: Chr4:20007938-20030785 bp, + strand  Genetic Position: Chr4, 7.76 cM, cytoband A3 Alliance: Ttpatm1Far page

Morphology of aortic lesions in Apoetm1Unc/Apoetm1Unc and Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:66419
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ-neomycin resistance cassette replaced part of the 5' untranslated region and exon 1 including the translational start codon. Immunoblot analysis of liver did not detect wild-type protein in homozygous mutant mice. (J:66419)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttpa Mutation:	23 strains or lines available

Original:	J:66419 Terasawa Y, et al., Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13830-4
All:	7 reference(s)