Gpi1<b-m3Neu> Chemically and radiation induced Allele Detail MGI Mouse (MGI:1932543)

Gpi1^b-m3Neu
Chemically and radiation induced Allele Detail

Summary

Symbol:	Gpi1^b-m3Neu
Name:	glucose-6-phosphate isomerase 1; mutant 3, Neuherberg
MGI ID:	MGI:1932543
Gene:	Gpi1 Location: Chr7:33900755-33929761 bp, - strand Genetic Position: Chr7, 19.46 cM
Alliance:	Gpi1^b-m3Neu page

Mutation
origin

Strain of Origin:

(102/El x C3H/El)F1

Mutation
description

Allele Type:		Chemically and radiation induced
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gpi1 Mutation:	68 strains or lines available

Notes

Allele produced after treating males with both triethylenemelamine (TEM) and a single dose of gamma-irradiation. Males were crossed to wild-type females and progeny were screened for GPI activity.

Heterozygotes are viable, fertile, and phenotypically normal except that they produce only 50% of normal GPI activity. Homozygous embryos die at an early stage of development, presumably due to blockage of glycolysis (J:3054).

References

Original:	J:3054 Merkle S, et al., A glucosephosphate isomerase (GPI) null mutation in Mus musculus: evidence that anaerobic glycolysis is the predominant energy delivering pathway in early post-implantation embryos. Comp Biochem Physiol B Biochem Mol Biol. 1992 Mar;101(3):309-14
All:	1 reference(s)

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