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Mmp9tm1Tvu
Targeted Allele Detail
Summary
Symbol: Mmp9tm1Tvu
Name: matrix metallopeptidase 9; targeted mutation 1, Thiennu H Vu
MGI ID: MGI:1932294
Synonyms: Gelatinase B-Null, GelB-, Mmp9-, MMP-9-, MMP9-, MMP-9KO, MMP-9 KO
Gene: Mmp9  Location: Chr2:164782700-164797770 bp, + strand  Genetic Position: Chr2, 85.27 cM, cytoband H1-H2
Alliance: Mmp9tm1Tvu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47297
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2 and all of intron 2 were replaced with a cassette containing the neomycin resistance gene driven by a PGK promoter. (J:47297)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 22 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mmp9tm1Tvu
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mmp9 Mutation:  49 strains or lines available
Notes
ES cell line = ZW4.
References
Original:  J:47297 Vu TH, et al., MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 1998 May 1;93(3):411-22
All:  274 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory