Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rargtm2Ipc
Name:	retinoic acid receptor, gamma; targeted mutation 2, Pierre Chambon
MGI ID:	MGI:1932114
Synonyms:	RARgamma2-
Gene:	Rarg  Location: Chr15:102143373-102165891 bp, - strand  Genetic Position: Chr15, 57.4 cM, cytoband E-F3
Alliance:	Rargtm2Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:12691
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette into exon 5 replaced part of the 5' untranslated region of the gene for the gamma2 isoform and the A2 region sequences up to the codon for amino acid 19 (nt 81-342). This disruption is predicted to selectively prevent the synthesis of the gamma2 isoform. RNase protection analysis of E10.5 embryos indicated that the mRNA encoding the gamma2 isoform was mutated in this allele, and that the wild-type transcript for the gamma1 isoform was transcribed. (J:12691)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

15 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarg Mutation:	151 strains or lines available

Original:	J:12691 Lohnes D, et al., Function of retinoic acid receptor gamma in the mouse. Cell. 1993 May 21;73(4):643-58
All:	4 reference(s)