Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Numbtm1Ynj
Name:	NUMB endocytic adaptor protein; targeted mutation 1, Yuh Nung Jan
MGI ID:	MGI:1932085
Synonyms:	floxed-numb, fnb, m-numb(flox), numbflox
Gene:	Numb  Location: Chr12:83840808-83968708 bp, - strand  Genetic Position: Chr12, 38.89 cM, cytoband D3
Alliance:	Numbtm1Ynj page

Germline Transmission:	Earliest citation of germline transmission: J:62712
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted into the gene that flanked exons 5 and 6. An frt-flanked neomycin selection cassette was also inserted in an adjacent intron, but had no effect on the normal expression of the gene. (J:62712)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Numb Mutation:	59 strains or lines available

Original:	J:62712 Zhong W, et al., Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6844-9
All:	14 reference(s)