Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Pou2af1tm1Rgr
Name:	POU domain, class 2, associating factor 1; targeted mutation 1, Robert Roeder
MGI ID:	MGI:1931863
Synonyms:	OCA-B-
Gene:	Pou2af1  Location: Chr9:51125008-51151380 bp, + strand  Genetic Position: Chr9, 27.95 cM
Alliance:	Pou2af1tm1Rgr page

Germline Transmission:	Earliest citation of germline transmission: J:35785
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced exons 2, 3, and 4. Northern blot analysis on spleen RNA from homozygous mice confirmed that no mRNA was expressed from this allele and immunoblot analysis on bone marrow derived cell lines from homozygous mice demonstrated an absence of encoded protein. (J:35785)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou2af1 Mutation:	15 strains or lines available

Original:	J:35785 Kim U, et al., The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature. 1996 Oct 10;383(6600):542-7
All:	12 reference(s)