Ncoa3tm1Jxu
Targeted Allele Detail
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Symbol: |
Ncoa3tm1Jxu |
Name: |
nuclear receptor coactivator 3; targeted mutation 1, Jianming Xu |
MGI ID: |
MGI:1931860 |
Synonyms: |
AIB1-, SRC-3- |
Gene: |
Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
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Alliance: |
Ncoa3tm1Jxu page
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Alveolar formation is reduced in the Ncoa3tm1Jxu/Ncoa3tm1Jxu mammary gland.
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:62724
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A TGK-neomycin resistance cassette replaced sequences spanning exon 2 through exon 13. The cassette introduced a lacZ sequence in frame with the endogenous promoter. The authors predict that the targeted allele would not produce a functional protein, but would produce a beta-galactosidase fusion protein controlled by the endogenous promoter. Western analysis did not detect wild-type protein in lactating mammary glands of homozygous mutant mice.
(J:62724)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ncoa3 Mutation: |
231 strains or lines available
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Original: |
J:62724 Xu J, et al., The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6379-84 |
All: |
37 reference(s) |
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