Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vtntm1Dgi
Name:	vitronectin; targeted mutation 1, David Ginsburg
MGI ID:	MGI:1931522
Synonyms:	VN-
Gene:	Vtn  Location: Chr11:78389946-78393151 bp, + strand  Genetic Position: Chr11, 46.74 cM
Alliance:	Vtntm1Dgi page

Germline Transmission:	Earliest citation of germline transmission: J:30296
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin cassette replaced all eight exons. Western blot analysis did not detect protein in plasma of homozygous mutant mice, and cell adhesion experiments with sera derived from homozygous mice demonstrated that serum spreading activity was absent. (J:30296)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vtn Mutation:	22 strains or lines available

Original:	J:30296 Zheng X, et al., Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12426-30
All:	27 reference(s)