Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Vegfatm1Pec
Name:	vascular endothelial growth factor A; targeted mutation 1, Peter Carmeliet
MGI ID:	MGI:1931047
Synonyms:	VEGF120
Gene:	Vegfa  Location: Chr17:46327919-46343295 bp, - strand  Genetic Position: Chr17, 22.79 cM
Alliance:	Vegfatm1Pec page

Germline Transmission:	Earliest citation of germline transmission: J:56003
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of exons 6 and 7 with a lox-P flanked neomycin cassette. The neomycin cassette was removed prior to blastocyst injection by Cre-mediated recombination in ES cells, resulting in the final allele. A highly soluble isoform of the encoded protein is expressed from this allele. (J:56003)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	68 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:	37 strains or lines available

Original:	J:56003 Carmeliet P, et al., Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments]. Nat Med. 1999 May;5(5):495-502
All:	32 reference(s)