Summary | Transgene origin | Transgene description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(MMTV-Notch4)3Rnc
Name:	transgene insertion 3, Robert Callahan
MGI ID:	MGI:1930200
Synonyms:	FF1 int-3, FVB-3, MMTV-int-3, MMTV LTR-INT3, TgN(MMTVInt3)3Rnc
Transgene:	Tg(MMTV-Notch4)3Rnc  Location: unknown
Alliance:	Tg(MMTV-Notch4)3Rnc page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(MMTV-Notch4)3Rnc expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Notch4 (MGI:107471)   Mutation details: A 7.5 kb genomic fragment derived from a Czech II mammary tumor was used to generate transgenic mice. The fragment contained MMTV envelope and 3' LTR sequences and a truncated portion of the mouse Notch4 gene. (J:11644)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(MMTV-Notch4)3Rnc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:11644 Jhappan C, et al., Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 1992 Mar;6(3):345-55
All:	3 reference(s)