Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd74tm1Doi
Name:	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID:	MGI:1927205
Synonyms:	Cd74tm1Dim, Ii-, Ii0
Gene:	Cd74  Location: Chr18:60936921-60945724 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Cd74tm1Doi page

Germline Transmission:	Earliest citation of germline transmission: J:4119
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of exons 2 and 3 with a neomycin resistance gene. (J:4119) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd74 Mutation:	33 strains or lines available

Original:	J:4119 Viville S, et al., Mice lacking the MHC class II-associated invariant chain. Cell. 1993 Feb 26;72(4):635-48
All:	32 reference(s)