Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Xrcc4tm1Fwa
Name:	X-ray repair complementing defective repair in Chinese hamster cells 4; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:1926771
Synonyms:	XRCC4-
Gene:	Xrcc4  Location: Chr13:89997033-90237727 bp, - strand  Genetic Position: Chr13, 45.5 cM
Alliance:	Xrcc4tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:65218
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of sequence encoding exon 3 of the Xrcc4 gene with a loxP-flanked neomycin cassette. This cassette was then removed by crossing mice with germline-Cre expressing mice to generate this allele containing a deletion of exon 3. Any potential transcript from this allele that spliced from exon 2 to exon 4 or 5 would harbor a frameshift mutation. (J:65218)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Xrcc4tm1Fwa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xrcc4 Mutation:	25 strains or lines available

Original:	J:65218 Gao Y, et al., A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23;95(7):891-902
All:	22 reference(s)