Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcf7l2tm1Cle
Name:	transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 1, Hans Clevers
MGI ID:	MGI:1926344
Synonyms:	Tcf-4-, Tcf4-, Tcf7l2-
Gene:	Tcf7l2  Location: Chr19:55730252-55922086 bp, + strand  Genetic Position: Chr19, 51.59 cM
Alliance:	Tcf7l2tm1Cle page

Germline Transmission:	Earliest citation of germline transmission: J:48968
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Gene disruption caused by insertion of a PGK-hygromycin selection cassette into the exon containing coding sequences for the N-terminal region of the DNA-binding HMG box. (J:48968) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:	56 strains or lines available

Original:	J:48968 Korinek V, et al., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet. 1998 Aug;19(4):379-83
All:	17 reference(s)