Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Chrnb2tm1Jpc
Name:	cholinergic receptor nicotinic beta 2 subunit; targeted mutation 1, Jean-Pierre Changeux
MGI ID:	MGI:1926253
Synonyms:	beta2-, beta2-KO
Gene:	Chrnb2  Location: Chr3:89660755-89671939 bp, - strand  Genetic Position: Chr3, 39.19 cM
Alliance:	Chrnb2tm1Jpc page

Germline Transmission:	Earliest citation of germline transmission: J:23256
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The start codon and the rest of exon 1 was replaced by a lacZ reporter gene and a neomycin resistance gene. (J:23256)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrnb2 Mutation:	32 strains or lines available

Original:	J:23256 Picciotto MR, et al., Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995 Mar 2;374(6517):65-7
All:	86 reference(s)