Ity3 MGI Mouse QTL Detail - MGI:1891848 - immunity to S. typhimurium 3

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Ity3 QTL Detail

Symbol

Ity3
Name

immunity to S. typhimurium 3

Feature Type

QTL
IDs

MGI:1891848
NCBI Gene: 112208
Candidate Genes

1 Gene

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Sequence Map

Chr1:131156308-165139464 bp
From MGI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.92 cM (cM position of peak correlated region/marker)
Mapping Data

4 experiments

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
QTL

2
Find Mice (IMSR)

0 strains or lines available

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NCBI Gene

112208

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Summaries

All 7

Phenotypes 3
Earliest

J:45962 Sebastiani G, et al., Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics. 1998 Jan 15;47(2):180-6
Latest

J:244656 Khan RT, et al., Genetic dissection of the ity3 locus identifies a role for ncf2 co-expression modules and suggests selp as a candidate gene underlying the ity3.2 locus. Front Immunol. 2014;5:375

Candidate Genes for Ity3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Tlr5	Chr1:182782353-182804010 (+)	J:108692	Congenic animals derived from resistant C57BL/6J and susceptible MOLF/Ei parentals were used to test the candidacy of Tlr5 for the Salmonella susceptibility QTL Ity3 (71.5 cM on chromosome 1). Introgression of MOLF/Ei-derived Ity3 onto a C57BL/6J geneticbackround included the Tlr5 locus. The following parentals and congeic lines were tested by injection with flagellin: C57BL/6J MOLF/Ei B6.MOLF-Slc11a1 Ity3 (homozygous for MOLF/Ei alleles at Tlr5) B6.MOLF-Slc11a1 Ity3 (heterozygous for C57BL/6J and MOLF/Ei alleles at Tlr5) B6.MOLF-Slc11a1 (homozygous for C57BL/6J alleles at Tlr5) Serum IL-6 and CXCL-1 were measured at different time points (0, 60, and 90 minutes) after flagellin administration. Congenic animals homozygous for MOLF/Ei alleles at Tlr5 (B6.MOLF-Slc11a1 Ity3)exhibited the strongest response to flagellen stimulation out of all lines tested as indicated by significantly higher levels of serum IL-6 and CXCL-1. Parental strain MOLF/Ei exhibits the lowest serum IL-6 and CXCL-1 levels compared to parental C57BL/6Jand all 3 congenic lines. The results indicate the effect of Tlr5 is dependent on strain background. Therefore, it is unlikely Tlr5 is responsible for the Ity3 susceptible phenotype.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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