Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdkn1btm1Kin
Name:	cyclin dependent kinase inhibitor 1B; targeted mutation 1, Kei-ichi Nakayama
MGI ID:	MGI:1888790
Synonyms:	p27-, p27Kip1, p27Kip1-
Gene:	Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Alliance:	Cdkn1btm1Kin page

Germline Transmission:	Earliest citation of germline transmission: J:33402
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette in reverse orientation replaced a 2.5kb sequence containing exons 1 and 2. This deletes the entire coding portion of the gene. Immunoblots of whole tissue lysates of the thymus demnonstrate the absence of protein product. (J:33402)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdkn1btm1Kin

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:	25 strains or lines available

Original:	J:33402 Nakayama K, et al., Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 1996 May 31;85(5):707-20
All:	31 reference(s)