Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpx2tm1Coh
Name:	glutathione peroxidase 2; targeted mutation 1, City of Hope, Beckman Research Institute
MGI ID:	MGI:1888703
Synonyms:	Gpx2-KO, Gpx2tm8Coh
Gene:	Gpx2  Location: Chr12:76839107-76842273 bp, - strand  Genetic Position: Chr12, 33.73 cM
Alliance:	Gpx2tm1Coh page

Germline Transmission:	Earliest citation of germline transmission: J:63988
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 1 of the gene. Northern blots of total RNA isolated from the middle small intestine of homozygous mutant mice showed no detectable transcript of the targeted gene when probed with an exon 1 probe. This line was established simultaneously with Gpx2tm2Coh. (J:63988)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpx2 Mutation:	8 strains or lines available

Original:	J:63988 Esworthy RS, et al., Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G426-36
All:	9 reference(s)