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Tfap2atm1Jae
Targeted Allele Detail
Summary
Symbol: Tfap2atm1Jae
Name: transcription factor AP-2, alpha; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1888387
Synonyms: AP-2 -
Gene: Tfap2a  Location: Chr13:40868778-40891852 bp, - strand  Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
Alliance: Tfap2atm1Jae page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33032
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 5, which encodes part of the DNA binding domain of the protein. (J:33032)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 96 assay results
In Structures Affected by this Mutation: 25 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tfap2a Mutation:  39 strains or lines available
References
Original:  J:33032 Schorle H, et al., Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature. 1996 May 16;381(6579):235-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory