Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ssttm1Ute
Name:	somatostatin; targeted mutation 1, Ute Hochgeschwender
MGI ID:	MGI:1888381
Synonyms:	Srif-, Sst-, Sst KO
Gene:	Sst  Location: Chr16:23708323-23709708 bp, - strand  Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
Alliance:	Ssttm1Ute page

Germline Transmission:	Earliest citation of germline transmission: J:70426
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An SV40-tk-neo cassette was inserted, thereby deleting the last 30 bp of exon 1 and the first 39 basepairs of inton 1. Successful recombination was shown by Southern blot. Northern blot indicated lack of transcript and radioimmunoassay demonstrated the lack of protein from homozygous mutants. (J:70426)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Sst Mutation:	35 strains or lines available

Original:	J:70426 Zeyda T, et al., Impairment in motor learning of somatostatin null mutant mice. Brain Res. 2001 Jul 6;906(1-2):107-14
All:	12 reference(s)