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Ptprcaptm1Tho
Targeted Allele Detail
Summary
Symbol: Ptprcaptm1Tho
Name: protein tyrosine phosphatase receptor type C polypeptide-associated protein; targeted mutation 1, Matt L Thomas
MGI ID: MGI:1888379
Synonyms: CD45AP (-)
Gene: Ptprcap  Location: Chr19:4204645-4206709 bp, + strand  Genetic Position: Chr19, 3.86 cM, cytoband B
Alliance: Ptprcaptm1Tho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58711
Parent Cell Line:  LSW1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The entire coding region (exon 2), with the exception of the initiator methionine, was replaced with a neomycin selection cassette. The cassette was inserted in the same transcriptional orientation as the gene in order to preserve the expression of an adjacent loci encoding coronin. Immunoblot analysis showed an absence of encoded protein in lysates derived from the thymi and spleens of homozygous mutant mice. Additional analysis showed that coronin protein levels were not affected by the targeting event. (J:58711)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptprcap Mutation:  20 strains or lines available
Notes
NOTE: In contrast to the findings reported here, Matsua et al. (J:48387) report that T and B lymphocytes isolated from Ptprcaptm1Tkda gene-targeted mice fail to respond as well as wild-type to antigen receptor stimulation, and display a diminished association between PTPRC and lymphocyte protein tyrosine kinase (Lck).
References
Original:  J:58711 Kung C, et al., CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction. Eur J Immunol. 1999 Dec;29(12):3951-5
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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