Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il5tm1Kopf
Name:	interleukin 5; targeted mutation 1, Manfred A Kopf
MGI ID:	MGI:1861948
Synonyms:	IL-5-, IL-5null
Gene:	Il5  Location: Chr11:53611621-53615930 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Alliance:	Il5tm1Kopf page

Germline Transmission:	Earliest citation of germline transmission: J:30867
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A neomycin resistance cassette was inserted into exon 3 of the gene. (J:30867)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:	32 strains or lines available

Original:	J:30867 Kopf M, et al., IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 1996 Jan;4(1):15-24
All:	75 reference(s)