About   Help   FAQ
H2-DMatm1Luc
Targeted Allele Detail
Summary
Symbol: H2-DMatm1Luc
Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Luc van Kaer
MGI ID: MGI:1861933
Synonyms: H2-DM-, H-2M-, H2-M-, H2-M0, H2-Malpha-
Gene: H2-DMa  Location: Chr17:34338667-34358075 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance: H2-DMatm1Luc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31625
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.5 kb fragment of the gene, encompassing the first and most of the second exon. (J:31625)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:  27 strains or lines available
References
Original:  J:31625 Martin WD, et al., H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 1996 Feb 23;84(4):543-50
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory