Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Gad2tm1Bae
Name:	glutamic acid decarboxylase 2; targeted mutation 1, Steinunn Baekkeskov
MGI ID:	MGI:1861928
Synonyms:	GAD 65 (-), GAD65 -
Gene:	Gad2  Location: Chr2:22512262-22583889 bp, + strand  Genetic Position: Chr2, 15.15 cM, cytoband A-B
Alliance:	Gad2tm1Bae page

Germline Transmission:	Earliest citation of germline transmission: J:44638
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 1, downstream of the translation initiation start site. Western blot analysis on brain extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:44638)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gad2 Mutation:	60 strains or lines available

Original:	J:44638 Kash SF, et al., Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14060-5
All:	13 reference(s)