Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: C3tm1Crr Name: complement component 3; targeted mutation 1, Michael C Carroll MGI ID: MGI:1861799 Synonyms: C3-, C3tm1Crr, mC3- Gene: C3  Location: Chr17:57510970-57535136 bp, - strand  Genetic Position: Chr17, 29.72 cM, cytoband E1-E3 Alliance: C3tm1Crr page

Total area of the placenta is lower in C3tm1Crr/C3tm1Crr mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:30152
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a PGK-neomycin resistance cassette into an exon of the C3 gene deleted sequences that code for the C-terminal region of the beta chain and the N-terminal region of the alpha chain, including the site for processing the pro-C3 molecule. ELISA testing did not detect C3 protein in serum of homozygous mutant mice. A C3 hemolytic assay did not detect functional C3 activity. (J:30152)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any C3 Mutation:	102 strains or lines available

Original:	J:30152 Wessels MR, et al., Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11490-4
All:	346 reference(s)