Wo Transgenic Allele Detail MGI Mouse (MGI:1861589)

Wo
Transgenic Allele Detail

Summary

Symbol:	Wo
Name:	wocko
MGI ID:	MGI:1861589
Gene:	Wo Location: unknown Genetic Position: Chr1, Syntenic
Alliance:	Wo page

Transgene
origin

Strain of Origin:

(C57BL/6J x DBA/2J)F1

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutations:		Insertion, Other
		Mutation details: The inserted transgenic construct contains a human vasopressin promoter region adjoined to a 1.9 kb fragment of a v-src gene from the Schmidt-Ruppin A strain of RSV. Southern blot analysis indicated that a single copy of the construct integrated into the genome of founder mice. Mapping data indicated that a complex rearrangement involving 6.3 cM of flanking genomic DNA had taken place at the transgene insertion site. The DNA was not deleted nor simply inverted and involved at least 4 breakpoints. (J:62376)
Inheritance:		Dominant

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Wo Mutation:	0 strains or lines available

Notes

This transgenic neurological mutation disrupts inner ear development. Mutant mice display a dominant behavioral phenotype of circling, hyperactivity, and head-tossing, like waltzer class mutants. Viability of homozygotes is reduced. Both structural and neural components of the inner ear were disrupted due to aberrant development (J:11245).

References

Original:	J:11245 Crenshaw EB 3rd, et al., Wocko, a neurological mutant generated in a transgenic mouse pedigree. J Neurosci. 1991 Jun;11(6):1524-30
All:	3 reference(s)

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